Data acquisition of triple quadrupole LC-MS for the citrinin determination

Data Acquisition Parameters Optimization of Quadrupole Orbitrap for Global Lipidomics on LC-MS/MS Time Frame

MSAcquisitionSimulator: data-dependent acquisition simulator for LC-MS shotgun proteomics

UNLABELLED Data-dependent acquisition (DDA) is the most common method used to control the acquisition process of shotgun proteomics experiments. While novel DDA approaches have been proposed, their evaluation is made difficult by the need of programmatic control of a mass spectrometer. An alternative is in silico analysis, for which suitable software has been unavailable. To meet this need, we ...

Improved Analysis of Trace Hormones in Drinking Water by LC/MS/MS (EPA 539) using the Agilent 6460 Triple Quadrupole LC/MS

A modification to the chromatographic conditions of EPA method 539 has been developed that reduces the total run time by more than a factor of three, while providing complete baseline resolution of all seven hormones and DLs that meet the EPA requirements. Response is 7 to 11 times more sensitive in negative mode compared to the use of ammonium hydroxide, and 1.7 to 2.4 times more sensitive in ...

Rapid Analysis of Vitamin D in Serum Using Triple Quadrupole LC/MS

A rapid method for the quantification of 25-OH D2 and 25-OH D3 in serum was developed using the Agilent 1200 Series Rapid Resolution LC (RRLC) system coupled with an Agilent 6430 Triple Quadrupole LC/MS with multimode ionization (MMI). Solid phase extraction minimizes matrix interferences and ion suppression, while enabling automation. Excellent linearity of quantification (R2 > 0.99) was obtai...

Sensitive single quadrupole LC/MS method for determination of lapatinib in human plasma.

A sensitive liquid chromatographic-single quadrupole mass spectrometric method was developed and validated for the determination of lapatinib in human plasma. Following a liquid-liquid extraction with methyl t-butyl ether, lapatinib and isotope labelled lapatinib, used as an internal standard (IS), were separated from the endogenous compounds on a Zorbax SB-C18 (150 x 3 mm, 3.5 μm) column. An i...